Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.

OBJECTIVE To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN Prospective case-control series. SETTING Academic referral center. PATIENTS Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant...

Anti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.

Can serum antibodies to myelin oligodendrocyte glycoprotein (MOG) be used as a marker of multiple sclerosis (MS) or to predict the course of MS? Recent articles present conflicting data in response to these questions. Berger et al.1 tested for presence of serum antibodies to MOG in patients experiencing a first clinically isolated syndrome suggestive of MS. Those who progressed almost invariabl...

Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders

Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...

Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis.

Myelin oligodendrocyte glycoprotein (MOG) is an integral membrane protein expressed in CNS oligodendrocytes and outermost myelin lamellae. Anti-MOG Abs cause myelin destruction (demyelination) in animal models of multiple sclerosis (MS); however, such pathogenic Abs have not yet been characterized in humans. Here, a method that specifically detects IgG binding to human MOG in its native, membra...

Sclerosis Family-Based Study Oligodendrocyte Glycoprotein: A Multiple The Human T Cell Response to Myelin